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Current status and future prospects for disease modification in osteoarthritis
Citation
Huang, Z and Ding, C and Li, T and Yu, SP, Current status and future prospects for disease modification in osteoarthritis, Rheumatology, 57 pp. iv108-iv123. ISSN 1462-0324 (2018) [Refereed Article]
Copyright Statement
Copyright 2017 The Author
DOI: doi:10.1093/rheumatology/kex496
Abstract
OA is a chronic, progressive and disabling joint disease, leading to a poor quality of life and an enormous social and economic burden. Current therapies for OA patients remain limited, which creates an area of huge unmet medical need. For some time, researchers have been looking for approaches that can inhibit the structural progression of OA. A variety of potential disease-modifying OA drugs have been developed, targeting cartilage, inflammatory pathways or subchondral bone. In addition, non-pharmacological therapies, including joint distraction and weight loss, draw increasing attention, with some showing disease-modifying potential. Thus we performed a comprehensive review to discuss the current status of disease-modifying therapies in OA and appraise the potentials of emerging novel agents.
Item Details
Item Type: | Refereed Article |
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Keywords: | cartilage, disease-modifying osteoarthritis drugs, non-pharmacological treatments, osteoarthritis, therapeutic targets |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
ID Code: | 123360 |
Year Published: | 2018 (online first 2017) |
Web of Science® Times Cited: | 13 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-01-03 |
Last Modified: | 2018-07-23 |
Downloads: | 0 |
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