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Miniaturised electrically actuated high pressure injection valve for portable capillary liquid chromatography


Li, Y and Pace, K and Nesterenko, PN and Paull, B and Stanley, R and Macka, M, Miniaturised electrically actuated high pressure injection valve for portable capillary liquid chromatography, Talanta, 180 pp. 32-35. ISSN 0039-9140 (2018) [Refereed Article]

Copyright Statement

© 2017 Elsevier B.V.

DOI: doi:10.1016/j.talanta.2017.11.061


A miniaturised high pressure 6-port injection valve has been designed and evaluated for its performance in order to facilitate the development of portable capillary high performance liquid chromatography (HPLC). The electrically actuated valve features a very small size (65 × 19 × 19 mm) and light weight (33 g), and therefore can be easily integrated in a miniaturised modular capillary LC system suited for portable field analysis. The internal volume of the injection valve was determined as 98 nL. The novel conical shape of the stator and rotor and the spring-loaded rotor performed well up to 32 MPa (4641 psi), the maximum operating pressure investigated. Suitability for application was demonstrated using a miniaturised capillary LC system applied to the chromatographic separation of a mixture of biogenic amines and common cations. The RSD (relative standard deviation) values of retention times and peak areas of 6 successive runs were 0.5–0.7% and 1.8–2.8% for the separation of biogenic amines, respectively, and 0.1–0.2% and 2.1–3.0% for the separation of cations, respectively. This performance was comparable with bench-top HPLC systems thus demonstrating the applicability of the valve for use in portable and miniaturised capillary HPLC systems.

Item Details

Item Type:Refereed Article
Keywords:miniaturised HPLC injection valve, capillary LC, portable analysis, portable chromatography, analytical separations, biogenic amines
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Li, Y (Mr Yan Li)
UTAS Author:Nesterenko, PN (Professor Pavel Nesterenko)
UTAS Author:Paull, B (Professor Brett Paull)
UTAS Author:Stanley, R (Professor Roger Stanley)
UTAS Author:Macka, M (Professor Mirek Macka)
ID Code:123314
Year Published:2018
Web of Science® Times Cited:14
Deposited By:Chemistry
Deposited On:2018-01-02
Last Modified:2019-03-06

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