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The gene SMART study: method, study design, and preliminary findings
Citation
Yan, X and Eynon, N and Papadimitriou, JD and Kuang, J and Munson, F and Tirosh, O and O'Keefe, L and Griffiths, LR and Ashton, KJ and Byrne, N and Pitsiladis, YP and Bishop, DJ, The gene SMART study: method, study design, and preliminary findings, BMC Genomics, 18, (Suppl 8) pp. 15-28. ISSN 1471-2164 (2017) [Refereed Article]
DOI: doi:10.1186/s12864-017-4186-4
Abstract
The gene SMART (genes and the Skeletal Muscle Adaptive Response to Training) Study aims to identify genetic variants
that predict the response to both a single session of High-Intensity Interval Exercise (HIIE) and to four weeks of HighIntensity
Interval Training (HIIT). While the training and testing centre is located at Victoria University, Melbourne, three
other centres have been launched at Bond University, Queensland University of Technology, Australia, and the
University of Brighton, UK. Currently 39 participants have already completed the study and the overall aim is to recruit
200 moderately-trained, healthy Caucasians participants (all males 18–45 y, BMI < 30). Participants will undergo exercise
testing and exercise training by an identical exercise program. Dietary habits will be assessed by questionnaire and
dietitian consultation. Activity history is assessed by questionnaire and current activity level is assessed by an activity
monitor. Skeletal muscle biopsies and blood samples will be collected before, immediately after and 3 h post HIIE, with
the fourth resting biopsy and blood sample taken after four weeks of supervised HIIT (3 training sessions per week).
Each session consists of eight to fourteen 2-min intervals performed at the pre-training lactate threshold (LT) power
plus 40 to 70% of the difference between pre-training lactate threshold (LT) and peak aerobic power (Wpeak). A number
of muscle and blood analyses will be performed, including (but not limited to) genotyping, mitochondrial respiration,
transcriptomics, protein expression analyses, and enzyme activity. The participants serve as their own controls. Even
though the gene SMART study is tightly controlled, our preliminary findings still indicate considerable individual
variability in both performance (in-vivo) and muscle (in-situ) adaptations to similar training. More participants are
required to allow us to better investigate potential underlying genetic and molecular mechanisms responsible for this
individual variability
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | The gene SMART (genes and the Skeletal Muscle Adaptive Response to Training) Study aims to identify genetic variants that predict the response to both a single session of High-Intensity Interval Exercise (HIIE) and to four weeks of HighIntensity Inte |
| Research Division: | Health Sciences |
| Research Group: | Sports science and exercise |
| Research Field: | Exercise physiology |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the health sciences |
| UTAS Author: | Byrne, N (Professor Nuala Byrne) |
| ID Code: | 123183 |
| Year Published: | 2017 |
| Web of Science® Times Cited: | 38 |
| Deposited By: | Health Sciences |
| Deposited On: | 2017-12-20 |
| Last Modified: | 2017-12-20 |
| Downloads: | 0 |
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