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Environmental and genetic determinants of two Vitamin D metabolites in healthy Australian children

Citation

Bima, A and Pezic, A and Sun, C and Cameron, FJ and Rodda, C and van der Mei, I and Chiaroni-Clarke, R and Dwyer, T and Kemp, A and Qu, J and Carlin, J and Ellis, JA and Ponsonby, AL, Environmental and genetic determinants of two Vitamin D metabolites in healthy Australian children, Journal of Pediatric Endocrinology and Metabolism, 30, (5) pp. 531-541. ISSN 0334-018X (2017) [Refereed Article]


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2017 Walter de Gruyter

DOI: doi:10.1515/jpem-2016-0088

Abstract

Background: Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood.

Methods: The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D3 and 1,25(OH)2D3 were measured by selective solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry. These concentrations were deseasonalised where relevant to remove the effect of month of sampling.

Results: Deseasonalised log 25(OH)D3 and 1,25(OH)2D3 concentrations were only moderately correlated (r = 0.42,  < 0.001). The following predicted both 25(OH)D3 and 1,25(OH)2D3: UVR 6 weeks before the interview, natural skin and eye colour, height and vitamin D allelic metabolism score. The following predicted 25(OH)D3 only: lifetime sunburns and vitamin D allelic synthesis score. Overall, 43.5% and 25.6% of variation in 25(OH)D3 and 1,25(OH)2D3 could be explained. After accounting for 25(OH)D3 concentrations, higher UVR 6 weeks before the interview and vitamin D allelic metabolism score further predicted 1,25(OH)2D3 concentrations.

Conclusions: Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)2D3 after accounting for 25(OH)D3 concentrations requires further evaluation.

Item Details

Item Type:Refereed Article
Keywords:1,25-dihydroxyvitamin D3, allelic score, determinants, ultraviolet radiation, vitamin D 25-hydroxyvitamin D3
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:van der Mei, I (Associate Professor Ingrid van der Mei)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
ID Code:123065
Year Published:2017
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-12-14
Last Modified:2018-06-26
Downloads:50 View Download Statistics

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