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Inflammatory Regulators of Redirected Neural Migration in the Injured Brain
journal contribution
posted on 2023-05-19, 14:05 authored by Nicole ByeNicole Bye, Turnley, AM, Morganti-Kossmann, CBrain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.
History
Publication title
NeurosignalsVolume
20Pagination
132-146ISSN
1424-862XDepartment/School
School of Pharmacy and PharmacologyPublisher
KargerPlace of publication
SwitzerlandRights statement
Copyright 2012 S. Karger AG, BaselRepository Status
- Restricted