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Inflammatory Regulators of Redirected Neural Migration in the Injured Brain

Citation

Bye, N and Turnley, AM and Morganti-Kossmann, C, Inflammatory Regulators of Redirected Neural Migration in the Injured Brain, Neurosignals, 20, (3) pp. 132-146. ISSN 1424-862X (2012) [Refereed Article]


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DOI: doi:10.1159/000336542

Abstract

Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.

Item Details

Item Type:Refereed Article
Keywords:review; neural migration; injured brain; inflammation
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Bye, N (Dr Nicole Bye)
ID Code:122960
Year Published:2012
Web of Science® Times Cited:6
Deposited By:Pharmacy
Deposited On:2017-12-07
Last Modified:2017-12-07
Downloads:0

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