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Association between electrocardiographic and echocardiographic markers of stage B heart failure and cardiovascular outcome
Citation
Yang, H and Marwick, TH and Wang, Y and Nolan, M and Negishi, K and Khan, F and Okin, PM, Association between electrocardiographic and echocardiographic markers of stage B heart failure and cardiovascular outcome, ESC Heart Failure, 4, (4) pp. 417-431. ISSN 2055-5822 (2017) [Refereed Article]
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Copyright Statement
Copyright 2017 the Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract
Methods and Results: Asymptomatic subjects ≥ 65 years without prior cardiac history, but with HF risks, were recruited from the local community. At baseline, they underwent clinical assessment, 12-lead ECG, and comprehensive echocardiography. New HF was assessed clinically at mean follow-up of 14 ± 4 months, and echocardiography was repeated in subjects with HF. Of the 447 study subjects (age 71 ± 5, 47% men) with SBHF, 13% had LVH, 32% impaired GLS, and 65% ≥ grade I DD (10% ≥ grade II DD). Forty were lost to follow-up. Clinical HF developed in 47 of 407, of whom 20% had echocardiographic LVH, 51% abnormal GLS, and 76% DD at baseline. Baseline LVH and abnormal GLS (not grade I DD) were independently associated with outcomes (clinical HF and cardiovascular death). Cornell-P and heart rate (not minSTmV5V6 nor PTFV1) were independently associated with LVH, impaired GLS, and DD. Cornell-P and minSTV5V6 (not heart rate nor PTFV1) were independently associated with outcomes. More ECG abnormalities improved sensitivity, but ECG-markers were not independent of or incremental to echocardiographic markers to predict HF in SBHF.
Conclusions: In this elderly study population, ECG markers showed low diagnostic sensitivity for non-ischaemic SBHF and low prognostic value for outcomes. Cornell-P and minSTmV5V6 had predictive value for outcomes in non-ischaemic SBHF independent of age, gender, and common comorbidities but were not incremental to echocardiography.
Item Details
Item Type: | Refereed Article |
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Keywords: | community screening, echocardiography, electrocardiography, stage B heart failure |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Yang, H (Ms Hilda Yang) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
UTAS Author: | Wang, Y (Ms Ying Wang) |
UTAS Author: | Nolan, M (Mr Mark Nolan) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
ID Code: | 122927 |
Year Published: | 2017 |
Web of Science® Times Cited: | 5 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2017-12-06 |
Last Modified: | 2018-06-26 |
Downloads: | 56 View Download Statistics |
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