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Liquid chromatography of carboxylic acids with potentiometric detection using a tungsten oxide electrode


Chen, Z and Alexander, PW and Haddad, PR, Liquid chromatography of carboxylic acids with potentiometric detection using a tungsten oxide electrode, Analytica Chimica Acta, 338, (1-2) pp. 41-49. ISSN 0003-2670 (1997) [Refereed Article]

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DOI: doi:10.1016/S0003-2670(96)00434-5


A tungsten oxide electrode was evaluated for potentiometric detection of carboxylic acids separated using various liquid Chromatographic methods, such as reversed-phase, ion-interaction and ion-exclusion. The separation of formic, acetic, propionic and butyric acids was performed using reversed-phase chromatography with 10% methanol/water solution at pH 6.0 as the eluent. The calibration plots were linear in the range 0.53.0 mmol, and the detection limits ranged ca. 0.010.05 mmol for the test acids. Potentiometric detection was also applied to ion-interaction chromatography, and the separation of carboxylic acids was improved by the use of 0.3 mmol decylammonium salicylate at pH 5.5 as an eluent. In this method, detection limits for formic, acetic, and propionic acids obtained were 0.01, 0.05, and 0.1 mmol, respectively. Comparison between the reversed-phase and ion-exclusion methods showed that the tungsten oxide electrode was more sensitive to the test acids for the ion-exclusion method, but gave a poorer separation for carboxylic acids using dilute sulphuric acid as the eluent. The potentiometric method of detection was compared with the UV method, and was shown to have advantages in terms of low cost, simplicity of construction and operation, and sensitivity when used in conjunction with the reversed-phase method of separation.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Instrumental methods (excl. immunological and bioassay methods)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Alexander, PW (Professor Peter Alexander)
UTAS Author:Haddad, PR (Professor Paul Haddad)
ID Code:12290
Year Published:1997
Web of Science® Times Cited:21
Deposited By:Chemistry
Deposited On:1997-08-01
Last Modified:2010-03-01

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