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Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age

Citation

Bowatte, G and Erbas, B and Lodge, CJ and Knibbs, LD and Gurrin, LC and Marks, GB and Thomas, PS and Johns, DP and Giles, GG and Hui, J and Dennekamp, M and Perret, JL and Abramson, MJ and Walters, EH and Matheson, MC and Dharmage, SC, Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age, European Respiratory Journal, 50, (4) ISSN 0903-1936 (2017) [Refereed Article]


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DOI: doi:10.1183/13993003.02357-2016

Abstract

Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val/val or ile/val genotypes. Over the 5-year period, higher NO2 exposures were associated with increased current asthma prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.

Item Details

Item Type:Refereed Article
Keywords:lung function, traffic-related pollution, asthma
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Johns, DP (Associate Professor David Johns)
ID Code:122848
Year Published:2017
Deposited By:Medicine (Discipline)
Deposited On:2017-12-01
Last Modified:2017-12-01
Downloads:0

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