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Amperometric detection of organic thiols at a tungsten wire electrode following their separation by liquid chromatography
journal contribution
posted on 2023-05-16, 10:56 authored by Hidayat, A, Hibbert, DB, Alexander, PWThe amperometric detection of thiols following their separation by reversed-phase chromatography and reaction into a post-column mercury carrier stream is shown to be a sensitive method when using a tungsten wire sensor as the working electrode in a three-electrode flow cell. Five organic thiols (cysteine, homocysteine, reduced glutathione, D,L-penicillamine and 2-mercaptopropionic acid) and thiourea could be separated within approx. 18 min. The analytical performance is comparable, and stability superior, to chemically modified electrodes previously reported.
History
Publication title
Journal of Chromatography BVolume
693Pagination
139-146ISSN
0378-4347Department/School
University CollegePublisher
Elsevier SciencePlace of publication
AmsterdamRepository Status
- Restricted