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Amperometric detection of organic thiols at a tungsten wire electrode following their separation by liquid chromatography

journal contribution
posted on 2023-05-16, 10:56 authored by Hidayat, A, Hibbert, DB, Alexander, PW
The amperometric detection of thiols following their separation by reversed-phase chromatography and reaction into a post-column mercury carrier stream is shown to be a sensitive method when using a tungsten wire sensor as the working electrode in a three-electrode flow cell. Five organic thiols (cysteine, homocysteine, reduced glutathione, D,L-penicillamine and 2-mercaptopropionic acid) and thiourea could be separated within approx. 18 min. The analytical performance is comparable, and stability superior, to chemically modified electrodes previously reported.

History

Publication title

Journal of Chromatography B

Volume

693

Pagination

139-146

ISSN

0378-4347

Department/School

University College

Publisher

Elsevier Science

Place of publication

Amsterdam

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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