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Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease

Citation

Norouzi, S and Adulcikas, J and Sohal, SS and Myers, S, Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease, Journal of Biomedical Science, 24 pp. 1-10. ISSN 1021-7770 (2017) [Refereed Article]


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DOI: doi:10.1186/s12929-017-0394-0

Abstract

Background: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zincís dynamic role as an insulin mimetic and a cellular second messenger that controls many processes associated with insulin signaling and other downstream pathways that are amendable to glycemic control.

Main body: Mechanisms that contribute to the decompartmentalization of zinc and dysfunctional zinc transporter mechanisms, including zinc signaling are associated with metabolic disease, including type 2 diabetes. The actions of the proteins involved in the uptake, storage, compartmentalization and distribution of zinc in cells is under intense investigation. Of these, emerging research has highlighted a role for several zinc transporters in the initiation of zinc signaling events in cells that lead to metabolic processes associated with maintaining insulin sensitivity and thus glycemic homeostasis.

Conclusion: This raises the possibility that zinc transporters could provide novel utility to be targeted experimentally and in a clinical setting to treat patients with insulin resistance and thus introduce a new class of drug target with utility for diabetes pharmacotherapy.

Item Details

Item Type:Refereed Article
Keywords:Zinc transporters, Type 2 diabetes, Insulin resistance
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Metabolism
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Norouzi, S (Ms Shaghayegh Norouzi)
Author:Adulcikas, J (Mr John Adulcikas)
Author:Sohal, SS (Dr Sukhwinder Sohal)
Author:Myers, S (Dr Stephen Myers)
ID Code:122610
Year Published:2017
Deposited By:Health Sciences
Deposited On:2017-11-21
Last Modified:2017-11-21
Downloads:0

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