Norouzi, S and Adulcikas, J and Sohal, SS and Myers, S, Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease, Journal of Biomedical Science, 24 pp. 1-10. ISSN 1021-7770 (2017) [Refereed Article]
Background: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zincís dynamic role as an insulin mimetic and a cellular second messenger that controls many processes associated with insulin signaling and other downstream pathways that are amendable to glycemic control.
Main body: Mechanisms that contribute to the decompartmentalization of zinc and dysfunctional zinc transporter mechanisms, including zinc signaling are associated with metabolic disease, including type 2 diabetes. The actions of the proteins involved in the uptake, storage, compartmentalization and distribution of zinc in cells is under intense investigation. Of these, emerging research has highlighted a role for several zinc transporters in the initiation of zinc signaling events in cells that lead to metabolic processes associated with maintaining insulin sensitivity and thus glycemic homeostasis.
Conclusion: This raises the possibility that zinc transporters could provide novel utility to be targeted experimentally and in a clinical setting to treat patients with insulin resistance and thus introduce a new class of drug target with utility for diabetes pharmacotherapy.
|Item Type:||Refereed Article|
|Keywords:||Zinc transporters, Type 2 diabetes, Insulin resistance|
|Research Division:||Biological Sciences|
|Research Group:||Biochemistry and Cell Biology|
|Research Field:||Cell Metabolism|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Author:||Norouzi, S (Mrs Shaghayegh Norouzi)|
|Author:||Adulcikas, J (Mr John Adulcikas)|
|Author:||Sohal, SS (Dr Sukhwinder Sohal)|
|Author:||Myers, S (Dr Stephen Myers)|
|Web of Science® Times Cited:||2|
|Deposited By:||Health Sciences|
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