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The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
Citation
Nunez, NK and Bennett, E and Chen, L and Pitrez, PM and Zosky, GR, The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific, Scientific Reports, 7 Article 15198. ISSN 2045-2322 (2017) [Refereed Article]
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Copyright Statement
© The Author(s) 2017. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Official URL: http://dx.doi.org/
DOI: doi:10.1038/s41598-017-15517-z
Abstract
Vitamin D defciency is increasing around the world and has been associated with the development of
asthma. This study aims to evaluate the efect of dietary vitamin D defciency at diferent life stages
on lung function using a murine model of allergic airways disease. BALB/c mice were challenged
intranasally with HDM or saline alone for 10 days. Twenty four hours after the last challenge, mice were
anesthetized and lung function was measured using the forced oscillation technique (FOT). Mice were
euthanized for assessment of infammation in the bronchoalveolar lavage (BAL) and total collagen
content in lung homogenates by ELISA. Vitamin D defciency impaired lung function in both male
and female mice, increasing tissue damping and elastance, however had no efect on HDM induced
infammation. The impact of vitamin D defciency was more evident in females. HDM also decreased
airway distensibility, but only in females and this response was not altered by vitamin D defciency. Our
data suggest that vitamin D defciency and HDM exposure have independent efects on lung mechanics
and that females are more susceptible to these efects. Vitamin D defciency may exacerbate lung
function defcits by having a direct, but independent, efect on parenchymal mechanics.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | vitamin D, house dust mite, asthma, lung function |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Nunez, NK (Ms Naile Nunez) |
| UTAS Author: | Bennett, E (Dr Ellen Bennett) |
| UTAS Author: | Chen, L (Dr Ling Chen) |
| UTAS Author: | Zosky, GR (Professor Graeme Zosky) |
| ID Code: | 122609 |
| Year Published: | 2017 |
| Funding Support: | National Health and Medical Research Council (1042235) |
| Web of Science® Times Cited: | 2 |
| Deposited By: | Medicine |
| Deposited On: | 2017-11-21 |
| Last Modified: | 2022-08-25 |
| Downloads: | 109 View Download Statistics |
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