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The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific


Nunez, NK and Bennett, E and Chen, L and Pitrez, PM and Zosky, GR, The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific, Scientific Reports, 7 Article 15198. ISSN 2045-2322 (2017) [Refereed Article]


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The Author(s) 2017. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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DOI: doi:10.1038/s41598-017-15517-z


Vitamin D defciency is increasing around the world and has been associated with the development of asthma. This study aims to evaluate the efect of dietary vitamin D defciency at diferent life stages on lung function using a murine model of allergic airways disease. BALB/c mice were challenged intranasally with HDM or saline alone for 10 days. Twenty four hours after the last challenge, mice were anesthetized and lung function was measured using the forced oscillation technique (FOT). Mice were euthanized for assessment of infammation in the bronchoalveolar lavage (BAL) and total collagen content in lung homogenates by ELISA. Vitamin D defciency impaired lung function in both male and female mice, increasing tissue damping and elastance, however had no efect on HDM induced infammation. The impact of vitamin D defciency was more evident in females. HDM also decreased airway distensibility, but only in females and this response was not altered by vitamin D defciency. Our data suggest that vitamin D defciency and HDM exposure have independent efects on lung mechanics and that females are more susceptible to these efects. Vitamin D defciency may exacerbate lung function defcits by having a direct, but independent, efect on parenchymal mechanics.

Item Details

Item Type:Refereed Article
Keywords:vitamin D, house dust mite, asthma, lung function
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Nunez, NK (Ms Naile Nunez)
UTAS Author:Bennett, E (Dr Ellen Bennett)
UTAS Author:Chen, L (Dr Ling Chen)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:122609
Year Published:2017
Funding Support:National Health and Medical Research Council (1042235)
Web of Science® Times Cited:2
Deposited By:Medicine
Deposited On:2017-11-21
Last Modified:2022-08-25
Downloads:109 View Download Statistics

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