Demmer, DL and Beilin, LJ and Hands, B and Burrows, S and Cox, KL and Oddy, WH and Mori, TA, Fatness and Fitness with cardio-metabolic risk factors in adolescents, Journal of Clinical Endocrinology and Metabolism pp. 1-15. ISSN 0021-972X (2017) [Refereed Article]
Objective: We aimed to compare the concurrent influences of cardiorespiratory fitness and fatness in relation to cardio-metabolic risk factors in adolescents from the Western Australian Pregnancy Cohort Study.
Design, Setting and Participants: Cross-sectional analysis was performed on 1128 participants with complete blood pressure data and 963 participants with complete blood biochemistry at 17 years of age. Fatness (waist circumference) and cardiorespiratory fitness (PWC170) were assessed as continuous measures to avoid the use of arbitrary cut points. Analyses used linear regression models adjusted for sex and potential lifestyle confounders.
Main Outcome Measure: Cardio-metabolic risk factors.
Results: Fatness was positively associated with systolic BP (coefficient: 0.19; p<0.001; beta coefficient: 0.20), triglycerides (log coefficient: 0.009; p<0.001; beta coefficient: 0.24), LDL-C (coefficient: 0.005; p=0.007; beta coefficient: 0.10) and hs-CRP (log coefficient: 0.05; p<0.001; beta coefficient: 0.35). There were no significant effects of fitness on any of these measures. A positive association between HOMA-IR and fatness (log coefficient: 0.02; p<0.001; beta coefficient: 0.33) was attenuated by fitness (log coefficient: -.0.18; p<0.001; beta coefficient: -0.18). Fatness was inversely associated with HDL-C in both sexes (coefficient: -0.006; p<0.001; beta coefficient: -0.23), while fitness was positively associated with HDL-C only in females (coefficient: 0.08; p=0.03; beta coefficient: 0.15).
Conclusions: The adverse effects of central adiposity seen across a broad range of cardio-metabolic risk factors were only partially ameliorated by fitness in this adolescent population.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Nutrition and Dietetics|
|Research Field:||Nutrition and Dietetics not elsewhere classified|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Author:||Oddy, WH (Professor Wendy Oddy)|
|Deposited By:||Menzies Institute for Medical Research|
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