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High-throughput gadobutrol-enhanced CMR: a time and dose optimization study
Citation
D'Angelo, T and Grigoratos, C and Mazziotti, S and Bratis, K and Pathan, F and Blandino, A and Elen, E and Puntmann, VO and Nagel, E, High-throughput gadobutrol-enhanced CMR: a time and dose optimization study, Journal of Cardiovascular Magnetic Resonance, 19, (1) Article 83. ISSN 1532-429X (2017) [Refereed Article]
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Copyright Statement
© 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s12968-017-0400-4
Abstract
Methods: This is a prospective, randomized, single-blind cross-over study performed in two different populations. The first population consisted of 30 patients with general indications for a rest CE-CMR who underwent cine-imaging before and immediately after intravenous administration of 0.1 mmol/kg body-weight of gadobutrol. Quantitative assessment of LV volumes and function was performed by the same reader in a randomized and blinded fashion. The second population was composed of 30 patients with indication to late gadolinium enhancement (LGE) imaging, which was performed twice at different gadobutrol doses (0.1 mmol/kg vs. 0.2 mmol/kg) and at different time delays (5 and 10 min vs. 5, 10, 15 and 20 min), within a maximal interval of 21 days. LGE images were analysed qualitatively (contrast-to-noise ratio) and quantitatively (LGE%-of-mass).
Results: Excellent correlation between pre- and post-contrast cine-imaging was found, with no difference of LV stroke volume and ejection fraction (p = 0.538 and p = 0.095, respectively). End-diastolic-volume and end-systolic-volume were measured significantly larger after contrast injection (p = 0.008 and p = 0.001, respectively), with a mean difference of 3.7 ml and 2.9 ml, respectively. LGE imaging resulted in optimal contrast-to-noise ratios 10 min post-injection for a gadobutrol dose of 0.1 mmol/kg body-weight and 20 min for a dose of 0.2 mmol/kg body-weight. At these time points LGE quantification did not significantly differ (0.1 mmol/kg: 11% (16.4); 0.2 mmol/kg: 12% (14.5); p = 0.059), showing excellent correlation (ICC = 0.957; p < 0.001).
Conclusion: A standardized CE-CMR rest protocol giving a dose of 0.1 mmol/kg of gadobutrol before cine-imaging and performing LGE 10 min after injection represents a fast low-dose protocol without significant loss of information in comparison to a longer protocol with cine-imaging before contrast injection and a higher dose of gadobutrol. This approach allows to reduce examination time and costs as well as minimize contrast-agent exposure.
Item Details
Item Type: | Refereed Article |
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Keywords: | cardiovascular magnetic resonance, dose optimization, gadobutrol, time optimization |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Pathan, F (Dr Faraz Pathan) |
ID Code: | 122452 |
Year Published: | 2017 |
Web of Science® Times Cited: | 33 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2017-11-15 |
Last Modified: | 2018-06-25 |
Downloads: | 70 View Download Statistics |
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