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Nitroxide-loaded hexosomes provide MRI contrast in vivo

Citation

Bye, N and Hutt, OE and Hinton, TM and Acharya, DP and Waddington, LJ and Moffat, BA and Wright, DK and Wang, HX and Mulet, X and Muir, BW, Nitroxide-loaded hexosomes provide MRI contrast in vivo, Langmuir, 30, (29) pp. 8898-8906. ISSN 0743-7463 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American Chemical Society

DOI: doi:10.1021/la5007296

Abstract

The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.

Item Details

Item Type:Refereed Article
Keywords:nanoparticles; hexosomes; MRI
Research Division:Technology
Research Group:Nanotechnology
Research Field:Nanobiotechnology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Bye, N (Dr Nicole Bye)
ID Code:122250
Year Published:2014
Web of Science® Times Cited:15
Deposited By:Pharmacy
Deposited On:2017-11-07
Last Modified:2017-11-20
Downloads:0

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