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Membrane estradiol signaling in the brain


Micevych, P and Dominguez, R, Membrane estradiol signaling in the brain, Frontiers in neuroendocrinology, 30, (3) pp. 315-327. ISSN 0091-3022 (2009) [Non Refereed Article]

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DOI: doi:10.1016/j.yfrne.2009.04.011


While the physiology of membrane-initiated estradiol signaling in the nervous system has remained elusive, a great deal of progress has been made toward understanding the activation of cell signaling. Membrane-initiated estradiol signaling activates G proteins and their downstream cascades, but the identity of membrane receptors and the proximal signaling mechanism(s) have been more difficult to elucidate. Mounting evidence suggests that classical intracellular estrogen receptor-α (ERα) and ERβ are trafficked to the membrane to mediate estradiol cell signaling. Moreover, an interaction of membrane ERα and ERβ with metabotropic glutamate receptors has been identified that explains the pleomorphic actions of membrane-initiated estradiol signaling. This review focuses on the mechanism of actions initiated by membrane estradiol receptors and discusses the role of scaffold proteins and signaling cascades involved in the regulation of nociception, sexual receptivity and the synthesis of neuroprogesterone, an important component in the central nervous system signaling.

Item Details

Item Type:Non Refereed Article
Keywords:Estrogen receptor, trafficking, hypothalamus, sexual reproduction
Research Division:Biological Sciences
Research Group:Zoology
Research Field:Animal cell and molecular biology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Dominguez, R (Dr Reymundo Dominguez)
ID Code:122241
Year Published:2009
Web of Science® Times Cited:131
Deposited By:Medicine
Deposited On:2017-11-06
Last Modified:2017-11-17

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