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Membrane estradiol signaling in the brain

journal contribution
posted on 2023-05-21, 19:09 authored by Micevych, P, Dominguez, R
While the physiology of membrane-initiated estradiol signaling in the nervous system has remained elusive, a great deal of progress has been made toward understanding the activation of cell signaling. Membrane-initiated estradiol signaling activates G proteins and their downstream cascades, but the identity of membrane receptors and the proximal signaling mechanism(s) have been more difficult to elucidate. Mounting evidence suggests that classical intracellular estrogen receptor-α (ERα) and ERβ are trafficked to the membrane to mediate estradiol cell signaling. Moreover, an interaction of membrane ERα and ERβ with metabotropic glutamate receptors has been identified that explains the pleomorphic actions of membrane-initiated estradiol signaling. This review focuses on the mechanism of actions initiated by membrane estradiol receptors and discusses the role of scaffold proteins and signaling cascades involved in the regulation of nociception, sexual receptivity and the synthesis of neuroprogesterone, an important component in the central nervous system signaling.

History

Publication title

Frontiers in neuroendocrinology

Volume

30

Pagination

315-327

ISSN

0091-3022

Department/School

Tasmanian School of Medicine

Publisher

Academic Press Inc Elsevier Science

Place of publication

United States

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

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