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The Association of Long-Term Traffic-Related Air Pollution Exposure with Asthma and Poor Lung Function in Middle Age
Citation
Bowatte, G and Erbas, B and Lodge, CJ and Knibbs, LD and Gurrin, LC and Marks, GB and Thomas, PS and Johns, DP and Giles, GG and Hui, J and Dennekamp, M and Perret, J and Abramson, MJ and Walters, EH and Matheson, MC and Dharmage, SC, The Association of Long-Term Traffic-Related Air Pollution Exposure with Asthma and Poor Lung Function in Middle Age, Respirology, 22 pp. 108-108. ISSN 1323-7799 (2017) [Refereed Article]
Abstract
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP)
on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more
robust measures of this association and potential gene–environment interactions using longitudinal data
from an established cohort study.
Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and
wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian
Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to
quantify associations and the potential modifying effect of glutathione S-transferase gene variants.
Living <200 m from a major road was associated with increased prevalence of current asthma and
wheeze, and lower lung function. The association between living <200 m from a major road and current
asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val/val or ile/val
genotypes. Over the 5-year period, higher NO2 exposures were associated with increased current asthma
prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1
null genotype.
TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in
middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant
mechanisms may play a role in these adverse health effects.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Air pollution, airflow obstruction |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Johns, DP (Associate Professor David Johns) |
| UTAS Author: | Walters, EH (Professor Haydn Walters) |
| ID Code: | 122123 |
| Year Published: | 2017 |
| Deposited By: | Medicine |
| Deposited On: | 2017-11-01 |
| Last Modified: | 2018-09-11 |
| Downloads: | 0 |
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