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Redefining Approaches to Asthma: Bridging the Gap Between Heparin and Its Anti-inflammatory Activities


Shastri, MD and Peterson, GM and Patel, RP, Redefining Approaches to Asthma: Bridging the Gap Between Heparin and Its Anti-inflammatory Activities, Current allergy and asthma reports, 17, (10) ISSN 1529-7322 (2017) [Letter or Note in Journal]

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DOI: doi:10.1007/s11882-017-0738-6


Heparin is widely used as an anticoagulant. Currently, this macromolecule is at the forefront in the field of glycobiology because of the recognition of its therapeutic potential in a wide range of medical conditions including inflammation. Heparin is composed of anticoagulant and non-anticoagulant molecules. A large body of evidence suggests that the anti-inflammatory activities of heparin are attributed to its non-anticoagulant molecules and are therefore independent to its anticoagulant effect. However, the potential therapeutic use of heparin in inflammatory conditions is hindered by the presence of anticoagulant molecules causing the risk of bleeding. Therefore, there is an emerging interest in identifying non-anticoagulant molecules of heparin responsible for the anti-inflammatory effects of the parent molecule. The present editorial commentary focuses on the non-anticoagulant applications of heparin for the management of asthma. The commentary concisely describes the plausible mechanisms of action of heparin involved in the therapy of asthma. It also discusses various approaches that are utilised for the development of novel non-anticoagulant analogues of heparin that possess the potent anti-asthmatic activity of the parent molecule but are devoid of anticoagulant effect. We also briefly outline potential future approaches for the use of this molecule as an effective anti-inflammatory agent.

Item Details

Item Type:Letter or Note in Journal
Keywords:Heparin, inflammation, asthma, anticoagulant, non-anticoagulant, anti-inflammatory
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:122031
Year Published:2017
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2017-10-27
Last Modified:2017-11-21

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