eCite Digital Repository
Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution
Citation
Nhiem Tran, N and Bye, N and Moffat, BA and Wright, DK and Cuddihy, A and Hinton, TM and Hawley, AM and Reynolds, NP and Waddington, LJ and Mulet, X and Turnley, AM and Morganti-Kossmann, MC and Muir, BW, Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution, Materials Science & Engineering C-Materials for Biological Applications, 71 pp. 584-593. ISSN 0928-4931 (2017) [Refereed Article]
Copyright Statement
Copyright 2016 Elsevier B.V.
DOI: doi:10.1016/j.msec.2016.10.028
Abstract
Engineered nanoparticles with multiple complementary imaging modalities are of great benefit to the rapid
treatment and diagnosis of disease in various organs. Herein, we report the formulation of cubosomes and
hexosomes that carry multiple amphiphilic imaging contrast agents in their self-assembled lipid bilayers. This
is the first report of the use of both near infrared fluorescent (NIRF) imaging and gadolinium lipid based magnetic
resonance (MR) imaging modalities in cubosomes and hexosomes. High-throughput screening was used to rapidly
optimize formulations with desirable nano-architectures and low in vitro cytotoxicity. The dual-modal imaging
nanoparticles in vivo biodistribution and organ specific contrast enhancement were then studied. The NIRF in
vivo imaging results indicated accumulation of both cubosomes and hexosomes in the liver and spleen of mice up
to 20 h post-injection. Remarkably, the biodistribution of the nanoparticle formulations was affected by the
mesophase (i.e. cubic or hexagonal), a finding of significant importance for the future use of these compounds,
with hexosomes showing higher accumulation in the spleen than the liver compared to cubosomes. Furthermore,
in vivo MRI data of animals injected with either type of lyotropic liquid crystal nanoparticle displayed enhanced
contrast in the liver and spleen.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Lipid; Nanoparticles; Cubosome; Hexosome; Multifunctional; Imaging; MRI; Biodistribution |
Research Division: | Biological Sciences |
Research Group: | Industrial biotechnology |
Research Field: | Nanobiotechnology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Bye, N (Dr Nicole Bye) |
ID Code: | 121828 |
Year Published: | 2017 |
Web of Science® Times Cited: | 42 |
Deposited By: | Pharmacy |
Deposited On: | 2017-10-17 |
Last Modified: | 2017-12-21 |
Downloads: | 0 |
Repository Staff Only: item control page