Saito, M and Wright, L and Negishi, K and Dwyer, N and Marwick, TH, Mechanics and prognostic value of left and right ventricular dysfunction in patients with systemic sclerosis, European Heart Journal Cardiovascular Imaging pp. 1-8. ISSN 2047-2404 (2017) [Refereed Article]
Methods and results: Speckle tracking LV strain parameters [global longitudinal strain (GLS) and global circumferential strain (GCS)] and tricuspid annular peak systolic velocity (Ts') were measured in 103 patients with SSc and 103 age- and gender-matched controls. Subjects were followed for a median of 3.4 years for heart failure-specific admission or death, and the association of the study parameters with outcome was assessed using Cox proportional hazards models. GLS, GCS, and Ts' were significantly impaired in patients with SSc, even without pulmonary hypertension, compared with controls. GCS (r2 = 0.07, P = 0.03) but not GLS (r2 = 0.04, P = 0.11) was associated with systolic pulmonary artery pressure. During follow-up, SSc patients (n = 17, 17%) had more events than controls (n = 7, 7%, P = 0.04). In SSc patients, GCS (but not GLS), Ts', and 6-minute walk distance (6MWD) were significantly associated with outcome. 6MWD and Ts' (but not GCS) were independently associated with outcome. A model based on age, gender, 6MWD, and GCS was significantly improved by adding by adding Ts' (P = 0.02).
Conclusion: RV dysfunction was associated with adverse outcome, independent of and incremental to clinical and LV deformation parameters in SSc. LV dysfunction appears to have less prognostic relevance than RV dysfunction.
|Item Type:||Refereed Article|
|Keywords:||left ventricle, prognosis, right ventricle, scleroderma, strain|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Saito, M (Dr Makoto Saito)|
|Author:||Wright, L (Ms Leah Wright)|
|Author:||Negishi, K (Dr Kazuaki Negishi)|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Deposited By:||Menzies Institute for Medical Research|
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