Marwick, TH and Whitmore, K and Nicholls, SJ and Stanton, T and Mitchell, G and Tonkin, A and Blizzard, C and Neil, A and Jones, C and Watts, GF, on behalf of the CAUGHT-CAD Investigators, Rationale and design of a trial to personalize risk assessment in familial coronary artery disease, American Heart Journal, 199 pp. 22-30. ISSN 0002-8703 (2018) [Refereed Article]
© 2017 Elsevier Inc. All rights reserved.
Study design: The proposed randomized controlled trial of the use of CCS will be targeted to 40- to 70-year-old first-degree relatives of patients with CAD onset <60 years old or second-degree relatives of patients with onset <50 years old. Control patients will undergo standard risk scoring and be blinded to CCS results. In the intervention group, primary prevention in patients undergoing CCS will be informed by this score. At 3 years, effectiveness will be assessed on change in plaque volume at computed tomography coronary angiography, the extent of which has been strongly linked to outcome.
Summary: The CAUGHT-CAD trial will provide evidence to inform the guidelines regarding the place of CCS in decision making regarding primary prevention of patients with a family history of premature disease.
|Item Type:||Refereed Article|
|Keywords:||coronary artery disease, risk assessment, family history, coronary artery calcium scoring, trial design|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Whitmore, K (Mrs Kristyn Whitmore)|
|UTAS Author:||Blizzard, C (Professor Leigh Blizzard)|
|UTAS Author:||Neil, A (Dr Amanda Neil)|
|Deposited By:||Menzies Institute for Medical Research|
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