Marwick, TH and Whitmore, K and Nicholls, SJ and Stanton, T and Mitchell, G and Tonkin, A and Blizzard, C and Neil, A and Jones, C and Watts, GF, on behalf of the CAUGHT-CAD Investigators, Rationale and design of a trial to personalize risk assessment in familial coronary artery disease, American Heart Journal, 199 pp. 22-30. ISSN 0002-8703 (2018) [Contribution to Refereed Journal]
© 2017 Elsevier Inc. All rights reserved.
Study design: The proposed randomized controlled trial of the use of CCS will be targeted to 40- to 70-year-old first-degree relatives of patients with CAD onset <60 years old or second-degree relatives of patients with onset <50 years old. Control patients will undergo standard risk scoring and be blinded to CCS results. In the intervention group, primary prevention in patients undergoing CCS will be informed by this score. At 3 years, effectiveness will be assessed on change in plaque volume at computed tomography coronary angiography, the extent of which has been strongly linked to outcome.
Summary: The CAUGHT-CAD trial will provide evidence to inform the guidelines regarding the place of CCS in decision making regarding primary prevention of patients with a family history of premature disease.
|Item Type:||Contribution to Refereed Journal|
|Keywords:||coronary artery disease, risk assessment, family history, coronary artery calcium scoring, trial design|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Whitmore, K (Mrs Kristyn Whitmore)|
|UTAS Author:||Blizzard, C (Professor Leigh Blizzard)|
|UTAS Author:||Neil, A (Associate Professor Amanda Neil)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
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