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Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis
Citation
Wang, X and Cicuttini, F and Jin, X and Wluka, AE and Han, W and Zhu, Z and Blizzard, L and Antony, B and Winzenberg, T and Jones, G and Ding, C, Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis, Osteoarthritis and Cartilage, 25, (8) pp. 1304-1312. ISSN 1063-4584 (2017) [Refereed Article]
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Copyright Statement
© 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
DOI: doi:10.1016/j.joca.2017.02.804
Abstract
Method: Symptomatic knee OA patients with low 25-(OH)D levels (12.5-60 nmol/l) were recruited for a multi-centre, randomised, placebo-controlled and double-blind trial. Participants (age 63 ± 7 years, 208 females) were allocated to either 50,000 IU monthly vitamin D3 (n = 209) or placebo (n = 204) for 24 months. Knee effusion-synovitis volume in suprapatellar and other regions was measured on magnetic resonance imaging (MRI) using OsiriX software. The intra-class correlation coefficients (ICCs) were used to test inter- and intra-rater reliabilities. The least significant change criterion was used to define the increase/decrease in effusion-synovitis volume.
Result: The reproducibilities of effusion-synovitis volume measurement were high with ICCs ranging from 0.93 to 0.99. Over 24 months, effusion-synovitis volume remained stable in the vitamin D group but increased in placebos with a significant between-group difference (-1.94 ml, 95% confidence interval (CI): -3.54, -0.33). This effect was evident in those with baseline effusion-synovitis and with suprapatellar effusion-synovitis. The proportion with an increase in effusion-synovitis volume was lower in the vitamin D group than placebo (risk ratio (RR): 0.87, 95% CI: 0.77, 0.97).
Conclusion: This highly reproducible effusion-synovitis volume measurement could be a promising outcome measure in OA trials. Vitamin D supplementation could retard the progression of effusion-synovitis which can potentially benefit people with an inflammatory OA phenotype.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | effusion, knee osteoarthritis, randomised controlled trial, synovitis, vitamin D |
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Rheumatology and Arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Skeletal System and Disorders (incl. Arthritis) |
| Author: | Wang, X (Ms Xia Wang) |
| Author: | Jin, X (Mr Xingzhong Jin) |
| Author: | Han, W (Dr Weiyu Han) |
| Author: | Zhu, Z (Mr Zhaohua Zhu) |
| Author: | Blizzard, L (Professor Leigh Blizzard) |
| Author: | Antony, B (Mr Benny Eathakkattu Antony) |
| Author: | Winzenberg, T (Professor Tania Winzenberg) |
| Author: | Jones, G (Professor Graeme Jones) |
| Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 121407 |
| Year Published: | 2017 |
| Web of Science® Times Cited: | 5 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2017-09-27 |
| Last Modified: | 2018-02-23 |
| Downloads: | 0 |
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