Zhu, Z and Laslett, LL and Han, W and Antony, B and Pan, F and Cicuttini, F and Jones, G and Ding, C, Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study, Osteoarthritis and Cartilage pp. 1-30. ISSN 1063-4584 (2017) [Refereed Article]
Methods: 837 participants were randomly selected from the local community and had MRI scans to assess knee OPs and other structures. OPs detected only by MRI but not by standard X-ray were defined as MRI-detected early OPs (MRI-OPs for short). OPs detected by both MRI and X-ray were defined as established-OPs.
Results: The prevalence of MRI-OPs was 50% while the prevalence of established-OPs was 10% and no-OPs was 40% at total tibiofemoral (TF) compartment at baseline. Compared with no-OPs, participants with MRI-OPs had greater risks of increased cartilage defects in all TF compartments (RR 1.37, 95%CI 1.07-1.74) and bone marrow lesions (BMLs) only in medial TF compartment (RR 1.49, 95%CI 1.06-2.11), after adjustment for age, sex, BMI, cartilage defects, BMLs and/or joint space narrowing; participants with established-OPs had greater cartilage volume loss at total (β -2.02, 95%CI -3.86, -0.17) and lateral tibial sites (β -5.63, 95%CI -9.93, -1.32), greater risks of increased cartilage defects in total (RR 1.66, 95%CI 1.15-2.40) and medial TF compartments (RR 1.49, 95%CI 1.20-1.69) and BMLs in all TF compartments (RR 1.88, 95%CI 1.22-2.89), after adjustment for covariates.
Conclusion: MRI-OPs were associated with changes in knee structures, and the asscoiations were similar but not as prominent as those for established-OPs. These suggest MRI-OPs may have a role to play in knee early-stage osteoarthritic progression.
|Item Type:||Refereed Article|
|Keywords:||osteophytes, knee osteoarthritis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Zhu, Z (Mr Zhaohua Zhu)|
|Author:||Laslett, LL (Dr Laura Laslett)|
|Author:||Han, W (Dr Weiyu Han)|
|Author:||Antony, B (Mr Benny Eathakkattu Antony)|
|Author:||Pan, F (Mr Feng Pan)|
|Author:||Jones, G (Professor Graeme Jones)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Deposited By:||Menzies Institute for Medical Research|
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