Ramkumar, S and Yang, H and Wang, Y and Nolan, M and Negishi, T and Negishi, K and Marwick, TH, Association of the active and passive components of left atrial deformation with left ventricular function, Journal of the American Society of Echocardiography, 30, (7) pp. 659-666. ISSN 0894-7317 (2017) [Refereed Article]
Methods: Echocardiography was undertaken in a community-based study of 576 participants ≥65 years of age with one or more risk factors (e.g., hypertension, diabetes mellitus, obesity). Strain analysis was conducted using a dedicated software package, using R-R gating. LV function was classified as normal in the presence of global longitudinal strain (GLS) (≤-18%) or global circumferential strain (GCS) (≤-22%). The associations between GLS or GCS and LA reservoir, conduit, and pump strain were assessed using univariate and multivariate linear regression.
Results: Patients (mean age 71 ± 5 years, 54% women) with reduced GLS had higher blood pressure and rates of diabetes and obesity (P < .05). LA reservoir strain and conduit strain were lower in the group with impaired GLS (38.2 ± 7.3% vs 39.9 ± 6.4% [P = .004] and 18.7 ± 5.7% vs 20.5 ± 5.1% [P < .001], respectively), but there was no difference in LA pump strain (19.5 ± 5.5% vs 19.3 ± 4.6%, P = .72). GLS was independently associated with LA reservoir and conduit strain (P < .05) but not independently associated with LA pump strain (P = .91). Reduced GCS was associated with a larger body mass index, male sex, and diabetes (P < .05). There were no differences in LA reservoir, conduit, and pump strain in patients with normal and abnormal GCS (P > .05).
Conclusions: The application of LA strain is specific to the component measured. LA pump strain is independent of LV mechanics.
|Item Type:||Refereed Article|
|Keywords:||Atrial function, Left atrium, Left ventricle, Strain|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Yang, H (Ms Hong Yang)|
|Author:||Wang, Y (Ms Ying Wang)|
|Author:||Nolan, M (Mr Mark Nolan)|
|Author:||Negishi, T (Dr Tomoko Negishi)|
|Author:||Negishi, K (Dr Kazuaki Negishi)|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Deposited By:||Menzies Institute for Medical Research|
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