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The third wave: Intermediate filaments in the maturing nervous system

Citation

Kirkcaldie, MTK and Dwyer, ST, The third wave: Intermediate filaments in the maturing nervous system, Molecular and cellular neurosciences, 84 pp. 30062-30063. ISSN 1044-7431 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Elsevier Ltd.

DOI: doi:10.1016/j.mcn.2017.05.010

Abstract

Intermediate filaments are critical for the extreme structural specialisations of neurons, providing integrity in dynamic environments and efficient communication along axons a metre or more in length. As neurons mature, an initial expression of nestin and vimentin gives way to the neurofilament triplet proteins and α-internexin, substituted by peripherin in axons outside the CNS, which physically consolidate axons as they elongate and find their targets. Once connection is established, these proteins are transported, assembled, stabilised and modified, structurally transforming axons and dendrites as they acquire their full function. The interaction between these neurons and myelinating glial cells optimises the structure of axons for peak functional efficiency, a property retained across their lifespan. This finely calibrated structural regulation allows the nervous system to maintain timing precision and efficient control across large distances throughout somatic growth and, in maturity, as a plasticity mechanism allowing functional adaptation.

Item Details

Item Type:Refereed Article
Keywords:neurofilaments, cytoskeleton, myelin, development
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Kirkcaldie, MTK (Dr Matthew Kirkcaldie)
Author:Dwyer, ST (Mr Samuel Dwyer)
ID Code:121376
Year Published:2017
Deposited By:Medicine (Discipline)
Deposited On:2017-09-26
Last Modified:2017-11-30
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