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Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

Citation

Stuart, K and King, AE and Fernandez-Martos, CM and Summers, MJ and Vickers, JC, Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model, Scientific Reports, 7, (1) Article 2764. ISSN 2045-2322 (2017) [Refereed Article]


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DOI: doi:10.1038/s41598-017-03016-0

Abstract

Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer’s disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer’s disease need to be designed to minimise a stress response that may exacerbate brain pathology.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, amyloid pathology, stress, environmental enrichment
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Stuart, K (Miss Kimberley Stuart)
Author:King, AE (Associate Professor Anna King)
Author:Fernandez-Martos, CM (Dr Carmen Fernandez-Martos)
Author:Summers, MJ (Dr Mathew Summers)
Author:Vickers, JC (Professor James Vickers)
ID Code:121357
Year Published:2017
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2017-09-26
Last Modified:2017-10-09
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