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Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model


Stuart, KE and King, AE and Fernandez-Martos, CM and Summers, MJ and Vickers, JC, Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model, Scientific Reports, 7, (1) Article 2764. ISSN 2045-2322 (2017) [Refereed Article]


Copyright Statement

Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1038/s41598-017-03016-0


Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer’s disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer’s disease need to be designed to minimise a stress response that may exacerbate brain pathology.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, amyloid pathology, stress, environmental enrichment
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Stuart, KE (Miss Kimberley Stuart)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Fernandez-Martos, CM (Dr Carmen Fernandez-Martos)
UTAS Author:Summers, MJ (Dr Mathew Summers)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:121357
Year Published:2017
Web of Science® Times Cited:11
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2017-09-26
Last Modified:2018-07-24
Downloads:91 View Download Statistics

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