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Measuring animal age with DNA methylation: from humans to wild animals

Citation

De Paoli-Iseppi, R and Deagle, BE and McMahon, CR and Hindell, MA and Dickinson, JL and Jarman, SN, Measuring animal age with DNA methylation: from humans to wild animals, Frontiers in Genetics, 8 Article 106. ISSN 1664-8021 (2017) [Refereed Article]


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Copyright Statement

Copyright 2017 De Paoli-Iseppi, Deagle, McMahon, Hindell, Dickinson and Jarman. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fgene.2017.00106

Abstract

DNA methylation (DNAm) is a key mechanism for regulating gene expression in animals and levels are known to change with age. Recent studies have used DNAm changes as a biomarker to estimate chronological age in humans and these techniques are now also being applied to domestic and wild animals. Animal age is widely used to track ongoing changes in ecosystems, however chronological age information is often unavailable for wild animals. An ability to estimate age would lead to improved monitoring of (i) population trends and status and (ii) demographic properties such as age structure and reproductive performance. Recent studies have revealed new examples of DNAm age association in several new species increasing the potential for developing DNAm age biomarkers for a broad range of wild animals. Emerging technologies for measuring DNAm will also enhance our ability to study age-related DNAm changes and to develop new molecular age biomarkers.

Item Details

Item Type:Refereed Article
Keywords:ageing, conservation, ecology, epigenetics, methylation, wild animals
Research Division:Technology
Research Group:Environmental Biotechnology
Research Field:Biodiscovery
Objective Division:Environment
Objective Group:Ecosystem Assessment and Management
Objective Field:Ecosystem Assessment and Management at Regional or Larger Scales
Author:De Paoli-Iseppi, R (Mr Ricardo De Paoli-Iseppi)
Author:Deagle, BE (Dr Bruce Deagle)
Author:Hindell, MA (Professor Mark Hindell)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
ID Code:121351
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-09-26
Last Modified:2017-11-14
Downloads:0

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