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Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic

Citation

Nicol, D and Eckstein, L and Morrison, M and Sherkow, JS and Otlowski, M and Whitton, T and Bubela, T and Burdon, KP and Chalmers, D and Chan, S and Charlesworth, J and Critchley, C and Crossley, M and de Lacey, S and Dickinson, JL and Hewitt, AW and Kamens, J and Kato, K and Kleiderman, E and Kodama, S and Liddicoat, J and Mackey, DA and Newson, AJ and Nielsen, J and Wagner, JK and McWhirter, RE, Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic, Genome Medicine, 9, (1) Article 85. ISSN 1756-994X (2017) [Contribution to Refereed Journal]


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Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s13073-017-0475-4

Abstract

Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPRmediated somatic cell therapy.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:genetics, ethics
Research Division:Law and Legal Studies
Research Group:Law in context
Research Field:Medical and health law
Objective Division:Law, Politics and Community Services
Objective Group:Justice and the law
Objective Field:Law reform
UTAS Author:Nicol, D (Professor Dianne Nicol)
UTAS Author:Eckstein, L (Dr Lisa Eckstein)
UTAS Author:Otlowski, M (Professor Margaret Otlowski)
UTAS Author:Whitton, T (Mr Thomas Whitton)
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
UTAS Author:Chalmers, D (Professor Don Chalmers)
UTAS Author:Charlesworth, J (Dr Jac Charlesworth)
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Mackey, DA (Professor David Mackey)
UTAS Author:Nielsen, J (Associate Professor Jane Nielsen)
UTAS Author:McWhirter, RE (Dr Rebekah McWhirter)
ID Code:121348
Year Published:2017
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-09-26
Last Modified:2018-12-13
Downloads:133 View Download Statistics

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