eCite Digital Repository

Community-based Intervention to improve cardiometabolic targets in patients with stroke: A randomized controlled trial


Olaiya, MT and Cadilhac, DAC and Kim, J and Nelson, MR and Srikanth, VK and Gerraty, RP and Bladin, CF and Fitzgerald, SM and Phan, T and Frayne, J and Thrift, AG, Community-based Intervention to improve cardiometabolic targets in patients with stroke: A randomized controlled trial, Stroke, 48, (9) pp. 2504-2510. ISSN 0039-2499 (2017) [Refereed Article]

Copyright Statement

2017 American Heart Association, Inc.

DOI: doi:10.1161/STROKEAHA.117.017499


Background and purpose: Many guidelines for secondary prevention of stroke focus on controlling cardiometabolic risk factors. We investigated the effectiveness of a management program for attaining cardiometabolic targets in survivors of stroke/transient ischemic attack.

Methods: Randomized controlled trial of survivors of stroke/transient ischemic attack aged ≥18 years. General practices were randomized to usual care (control) or an intervention comprising specialist review of care plans and nurse education in addition to usual care. The outcome is attainment of pre-defined cardiometabolic targets based on Australian guidelines. Multivariable regression was undertaken to determine efficacy and identify factors associated with attaining targets.

Results: Overall, 283 subjects were randomized to the intervention and 280 to controls. Although we found no between-group difference in overall cardiometabolic targets achieved at 12 months, the intervention group more often achieved control of low-density lipoprotein cholesterol (odds ratio, 1.97; 95% confidence interval, 1.18-3.29) than controls. At 24 months, no between-group differences were observed. Medication adherence was ≥ 80% at follow-up, but uptake of lifestyle/behavioral habits was poor. Older age, being male, being married/living with partner, and having greater functional ability or a history of diabetes mellitus were associated with attaining targets.

Conclusions: The intervention in this largely negative trial only had a detectable effect on attaining target for lipids but not for other factors at 12 months or any factor at 24 months. This limited effect may be attributable to inadequate uptake of behavioral/lifestyle interventions, highlighting the need for new or better approaches to achieve meaningful behavioral change.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular diseases, goals, randomized controlled trial, risk factors, stroke
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Nelson, MR (Professor Mark Nelson)
UTAS Author:Srikanth, VK (Dr Velandai Srikanth)
ID Code:121332
Year Published:2017
Web of Science® Times Cited:25
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-09-23
Last Modified:2022-08-30

Repository Staff Only: item control page