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Monoamine transporters: vulnerable and vital doorkeepers


Lin, Z and Canales, JJ and Bjorgvinsson, T and Thomsen, M and Qu, H and Liu, Q-R and Torres, GE and Caine, SB, Monoamine transporters: vulnerable and vital doorkeepers, Progress in molecular biology and translational science, 98 pp. 1-46. ISSN 1877-1173 (2011) [Refereed Article]


Copyright Statement

Copyright 2011 Elsevier

DOI: doi:10.1016/B978-0-12-385506-0.00001-6


Transporters of dopamine, serotonin, and norepinephrine have been empirically used as medication targets for several mental illnesses in the last decades. These protein-targeted medications are effective only for subpopulations of patients with transporter-related brain disorders. Since the cDNA clonings in early 1990s, molecular studies of these transporters have revealed a wealth of information about the transporters' structure-activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics, and the diseases related to the human genes encoding these transporters among related regulators. Such new information creates a unique opportunity to develop transporter-specific medications based on SAR, mRNA, DNA, and perhaps transporter trafficking regulation for a number of highly relevant diseases including substance abuse, depression, schizophrenia, and Parkinson's disease.

Item Details

Item Type:Refereed Article
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Canales, JJ (Professor Juan Canales)
ID Code:121306
Year Published:2011
Web of Science® Times Cited:150
Deposited By:Psychology
Deposited On:2017-09-21
Last Modified:2017-10-12
Downloads:133 View Download Statistics

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