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Monoamine transporters: vulnerable and vital doorkeepers
Citation
Lin, Z and Canales, JJ and Bjorgvinsson, T and Thomsen, M and Qu, H and Liu, Q-R and Torres, GE and Caine, SB, Monoamine transporters: vulnerable and vital doorkeepers, Progress in molecular biology and translational science, 98 pp. 1-46. ISSN 1877-1173 (2011) [Refereed Article]
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Copyright Statement
Copyright 2011 Elsevier
DOI: doi:10.1016/B978-0-12-385506-0.00001-6
Abstract
Transporters of dopamine, serotonin, and norepinephrine have been empirically used as medication targets for several mental illnesses in the last decades. These protein-targeted medications are effective only for subpopulations of patients with transporter-related brain disorders. Since the cDNA clonings in early 1990s, molecular studies of these transporters have revealed a wealth of information about the transporters' structure-activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics, and the diseases related to the human genes encoding these transporters among related regulators. Such new information creates a unique opportunity to develop transporter-specific medications based on SAR, mRNA, DNA, and perhaps transporter trafficking regulation for a number of highly relevant diseases including substance abuse, depression, schizophrenia, and Parkinson's disease.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Psychology |
| Research Group: | Biological psychology |
| Research Field: | Behavioural neuroscience |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Mental health |
| UTAS Author: | Canales, JJ (Professor Juan Canales) |
| ID Code: | 121306 |
| Year Published: | 2011 |
| Web of Science® Times Cited: | 150 |
| Deposited By: | Psychology |
| Deposited On: | 2017-09-21 |
| Last Modified: | 2017-10-12 |
| Downloads: | 133 View Download Statistics |
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