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Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking


Pei, Y and Lee, J and Leo, D and Gainetdinov, RR and Hoener, MC and Canales, JJ, Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking, Neuropsychopharmacology, 39, (10) pp. 2299-2308. ISSN 0893-133X (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American College of Neuropsychopharmacology

DOI: doi:10.1038/npp.2014.88


The trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for medication development in addiction because of its ability to regulate dopamine (DA) transmission. We tested in rats the efficacy of RO5203648 and RO5256390, partial and full TAAR1 agonists, respectively, in models of cocaine relapse. Using a model of context-induced relapse, both RO5203648 and RO5256390 dose-dependently suppressed cocaine seeking after a 2-week period of withdrawal from chronic cocaine self-administration. In a model of extinction-reinstatement, RO5203648 completely inhibited cocaine-primed reinstatement of cocaine seeking. At doses that effectively suppressed cocaine seeking neither RO5203648 nor RO5256390 altered responding maintained by a natural reward. Moreover, fast scan cyclic voltammetry data showed that RO5203648 prevented cocaine-induced DA overflow in the nucleus accumbens without altering DA half-life, suggesting that the partial TAAR1 agonist attenuated cocaine-stimulated DA overflow by mechanisms other than direct interference with DA uptake. Collectively, these data provide strong evidence in support of TAAR1 as a neuropharmacological target for the treatment of cocaine addiction.

Item Details

Item Type:Refereed Article
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Canales, JJ (Professor Juan Canales)
ID Code:121261
Year Published:2014
Web of Science® Times Cited:58
Deposited By:Psychology
Deposited On:2017-09-20
Last Modified:2017-10-30

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