Gene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology. The aim of the present article is to provide an overview of this rapidly expanding subject. In particular, we review some fundamental concepts of systems biology and discuss the role of network modelling in understanding complex biological systems. Several commonly used network modelling paradigms are surveyed with emphasis on their practical use in systems biology research.

Item Type:	Refereed Article
Keywords:	gene regulatory network, systems biology, bioinformatics
Research Division:	Biological Sciences
Research Group:	Genetics
Research Field:	Genetics not elsewhere classified
Objective Division:	Expanding Knowledge
Objective Group:	Expanding knowledge
Objective Field:	Expanding knowledge in the biological sciences
UTAS Author:	Charleston, MA (Professor Michael Charleston)
ID Code:	121082
Year Published:	2011
Deposited By:	Mathematics and Physics
Deposited On:	2017-09-08
Last Modified:	2017-11-02
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