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Both dietary fat and vitamin D deficiency have been linked with increased incidence of non-alcoholic fatty liver disease and insulin resistance. While sex differences in disease prevalence and severity are well known, the impact on disease pathogenesis remains unclear. To further explore the effect of these exposures on metabolic function, C57BL/6 male and female mice were weaned onto one of four diets; low fat vitamin D replete, low fat vitamin D deficient, or two high fat diets, one vitamin D replete and one deficient. Visceral fat, hepatic adiposity, and insulin resistance were measured after five and a half weeks. Vitamin D deficiency, independent of dietary fat, increased hepatic fat accumulation in both sexes (p = 0.003), although did not increase hepatic expression of interleukin-6 (p = 0.92) or tumor necrosis factor-α (p = 0.78). Males were observed to have greater insulin resistance (glucose area under the curve: p < 0.001, homeostatic model assessment for insulin resistance: p = 0.046), and have greater visceral adiposity (p < 0.001), while female mice had greater hepatic fat accumulation (p < 0.001). This study is the first to demonstrate vitamin D deficiency alone can cause hepatic accumulation while also being the first to observe higher liver fat percentages in female mice.

Item Type:	Refereed Article
Keywords:	vitamin D, metabolic disease, insulin, liver adiposity
Research Division:	Medical and Health Sciences
Research Group:	Clinical Sciences
Research Field:	Endocrinology
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Diabetes
Author:	Giblin, R (Ms Ryan Giblin)
Author:	Bennet, E (Ms Ellen Bennett)
Author:	Zosky, GR (Associate Professor Graeme Zosky)
Author:	Dwyer, RM (Dr Renee Dwyer)
ID Code:	121061
Year Published:	2017
Deposited By:	Medicine (Discipline)
Deposited On:	2017-09-08
Last Modified:	2017-09-13
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