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Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology

Citation

Chong, WC and Shastri, M and Eri, R, Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology, International Journal of Molecular Sciences, 18, (4) pp. 1-19. ISSN 1661-6596 (2017) [Refereed Article]

DOI: doi:10.3390/ijms18040771

Abstract

The endoplasmic reticulum (ER) is a complex protein folding and trafficking organelle. Alteration and discrepancy in the endoplasmic reticulum environment can affect the protein folding process and hence, can result in the production of misfolded proteins. The accumulation of misfolded proteins causes cellular damage and elicits endoplasmic reticulum stress. Under such stress conditions, cells exhibit reduced functional synthesis, and will undergo apoptosis if the stress is prolonged. To resolve the ER stress, cells trigger an intrinsic mechanism called an unfolded protein response (UPR). UPR is an adaptive signaling process that triggers multiple pathways through the endoplasmic reticulum transmembrane transducers, to reduce and remove misfolded proteins and improve the protein folding mechanism, in order to improve and maintain endoplasmic reticulum homeostasis. An increasing number of studies support the view that oxidative stress has a strong connection with ER stress. During the protein folding process, reactive oxygen species are produced as by-products, leading to impaired reduction-oxidation (redox) balance conferring oxidative stress. As the protein folding process is dependent on redox homeostasis, the oxidative stress can disrupt the protein folding mechanism and enhance the production of misfolded proteins, causing further ER stress. It is proposed that endoplasmic reticulum stress and oxidative stress together play significant roles in the pathophysiology of bowel diseases.

Item Details

Item Type:Refereed Article
Keywords:Gastrointestinal, ER stress, Colitis, Oxidative stress
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Chong, WC (Mr Wai Chong)
Author:Shastri, M (Mr Madhur Shastri)
Author:Eri, R (Dr Raj Eri)
ID Code:121024
Year Published:2017
Deposited By:Health Sciences
Deposited On:2017-09-07
Last Modified:2017-09-07
Downloads:0

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