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Nanotube molecular probes: DNA hybridization using single walled carbon nanotubes as biomarkers


Cao, C and Hong, S and Choi, J-B and Kim, Y-J and Baik, S and Hwang, E-S and Jung, H-J and Cha, C-Y, Nanotube molecular probes: DNA hybridization using single walled carbon nanotubes as biomarkers, Proceedings of IEEE SENSORS 2006, 22-25 October, Daegu, Korea, pp. 1272-1275. ISSN 1930-0395 (2006) [Refereed Conference Paper]

Copyright Statement

Copyright 2006 IEEE

DOI: doi:10.1109/ICSENS.2007.355861


Single walled carbon nanotubes (SWNTs) hold particular advantage as optical nano-bio markers because they exhibit strong Raman signals. Such signals do not blink or photobleach under prolonged excitation. Here, new single-stranded DNA conjugated SWNT probes were developed to locate a particular sequence of DNA within a complex genome. Chromosomal DNAs of human fibroblast and Escherichia coli (E.coli) were used as a target and a control, respectively. Southern blotting, which uses photostable Raman signals of nanotubes instead of fluorescent dyes, demonstrated excellent sensitivity and specificity of the probes. The results showed SWNTs' possibility of being generic nano-bio markers for precise detection of specific kinds of genes.

Item Details

Item Type:Refereed Conference Paper
Keywords:probes, DNA, carbon nanotubes, biomarkers, biomedical optical imaging, optical sensors, photobleaching, sequences, genomics, bioinformatics
Research Division:Biological Sciences
Research Group:Industrial biotechnology
Research Field:Nanobiotechnology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Hong, S (Dr Sanghyun Hong)
ID Code:120961
Year Published:2006
Deposited By:Plant Science
Deposited On:2017-09-04
Last Modified:2017-11-13

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