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Nano-bio applications using carbon nanotube-biomolecule conjugates


Hwang, E-S and Chengfan, C and Hong, S and Jung, H-J and Cha, C-Y and Choi, J-B and Kim, Y-J and Baik, S, Nano-bio applications using carbon nanotube-biomolecule conjugates, International Journal of the Korean Society of Precision Engineering, 23, (3) pp. 179-186. ISSN 1229-8557 (2006) [Refereed Article]

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Single-walled carbon nanotubes (SWNT) exhibit strong Raman signals as well as fluorescence emissions in the near infrared regions where most biomolecules are transparent. Such signals do not blink or photobleach under prolonged excitation, which is advantageous to optical nano-bio marker applications. In this paper, single walled-carbon nanotubes are conjugated with specific types of single-stranded DNA in order to detect oligonucleotides of corresponding complimentary sequences. Dot blotting experiments and comparative Raman spectroscopy observations demonstrated excellent sensitivity and specificity of carbon nanotube-DNA probes. The results show the possibility of using SWNT as generic nano-bio markers for the precise detection of specific kinds of genes.

Item Details

Item Type:Refereed Article
Keywords:biomolecule, conjugate, fluorescence, nano-bio markers, Raman spectroscopy, single walled carbon nanotubes (SWNT)
Research Division:Biological Sciences
Research Group:Industrial biotechnology
Research Field:Nanobiotechnology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Hong, S (Dr Sanghyun Hong)
ID Code:120960
Year Published:2006
Deposited By:Plant Science
Deposited On:2017-09-04
Last Modified:2017-11-28

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