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Nano-bio applications using carbon nanotube-biomolecule conjugates
Citation
Hwang, E-S and Chengfan, C and Hong, S and Jung, H-J and Cha, C-Y and Choi, J-B and Kim, Y-J and Baik, S, Nano-bio applications using carbon nanotube-biomolecule conjugates, International Journal of the Korean Society of Precision Engineering, 23, (3) pp. 179-186. ISSN 1229-8557 (2006) [Refereed Article]
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Abstract
Single-walled carbon nanotubes (SWNT) exhibit strong Raman signals as well as fluorescence emissions in the
near infrared regions where most biomolecules are transparent. Such signals do not blink or photobleach under
prolonged excitation, which is advantageous to optical nano-bio marker applications. In this paper, single walled-carbon
nanotubes are conjugated with specific types of single-stranded DNA in order to detect oligonucleotides of
corresponding complimentary sequences. Dot blotting experiments and comparative Raman spectroscopy observations
demonstrated excellent sensitivity and specificity of carbon nanotube-DNA probes. The results show the possibility of
using SWNT as generic nano-bio markers for the precise detection of specific kinds of genes.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | biomolecule, conjugate, fluorescence, nano-bio markers, Raman spectroscopy, single walled carbon nanotubes (SWNT) |
| Research Division: | Technology |
| Research Group: | Nanotechnology |
| Research Field: | Nanobiotechnology |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Chemical Sciences |
| UTAS Author: | Hong, S (Dr Sanghyun Hong) |
| ID Code: | 120960 |
| Year Published: | 2006 |
| Deposited By: | Plant Science |
| Deposited On: | 2017-09-04 |
| Last Modified: | 2017-11-28 |
| Downloads: | 0 |
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