eCite Digital Repository
Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response
Citation
Liu, GS and Chan, EC and Higuchi, M and Dusting, GJ and Jiang, F, Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response, Cells, 1, (4) pp. 976-993. ISSN 2073-4409 (2012) [Refereed Article]
 | PDF 235Kb |
Copyright Statement
© 2012 by the authors. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) https://creativecommons.org/licenses/by/3.0/
Abstract
In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evidence indicates that reactive oxygen species may act to promote both the initiation of adipocyte lineage commitment of precursor or stem cells, and the terminal differentiation of preadipocytes to mature adipose cells. These can involve redox regulation of pathways mediated by receptor tyrosine kinases, peroxisome proliferator-activated receptor γ (PPARγ), PPARγ coactivator 1α (PGC-1α), AMP-activated protein kinase (AMPK), and CCAAT/enhancer binding protein β (C/EBPβ). However, the precise roles of ROS in adipogenesis in vivo remain controversial. More studies are needed to delineate the roles of reactive oxygen species and redox signaling mechanisms, which could be either positive or negative, in the pathogenesis of obesity and related metabolic disorders.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | adipocyte, adipogenesis, differentiation, obesity, oxidative stress, reactive oxygen species, redox regulation |
| Research Division: | Technology |
| Research Group: | Medical Biotechnology |
| Research Field: | Gene and Molecular Therapy |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Inherited Diseases (incl. Gene Therapy) |
| Author: | Liu, GS (Dr Guei-Sheung Liu) |
| ID Code: | 120863 |
| Year Published: | 2012 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2017-08-31 |
| Last Modified: | 2017-09-08 |
| Downloads: | 7 View Download Statistics |
Repository Staff Only: item control page