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NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses


Jiang, F and Liu, GS and Dusting, GJ and Chan, EC, NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses, Redox Biology, 2 pp. 267-272. ISSN 2213-2317 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)

DOI: doi:10.1016/j.redox.2014.01.012


Uncontrolled fibrosis in organs like heart, kidney, liver and lung is detrimental and may lead to end-stage organ failure. Currently there is no effective treatment for fibrotic disorders. Transforming growth factor (TGF)-β has a fundamental role in orchestrating the process of fibrogenesis; however, interventions directly targeting TGF-β would have undesired systemic side effects due to the multiple physiological functions of TGF-β. Further characterization of the downstream signaling pathway(s) involved in TGF-β-mediated fibrosis may lead to discovery of novel treatment strategies for fibrotic disorders. Accumulating evidence suggests that Nox4 NADPH oxidase may be an important downstream effector in mediating TGF-β-induced fibrosis, while NADPH oxidase-dependent redox signaling may in turn regulate TGF-β/Smad signaling in a feed-forward manner. It is proposed that pharmacological inhibition of the Nox4 function may represent a novel approach in treatment of fibrotic disorders.

Item Details

Item Type:Refereed Article
Keywords:fibrosis, NADPH oxidase, Nox4, Redox signaling, transforming growth factor-β
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biotechnology
Research Field:Gene and molecular therapy
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Liu, GS (Associate Professor Guei-Sheung Liu)
ID Code:120862
Year Published:2014
Web of Science® Times Cited:178
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-31
Last Modified:2017-11-03
Downloads:119 View Download Statistics

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