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Evidence for the recruitment of autophagic vesicles in human brain after stroke

Citation

Frugier, T and Taylor, JM and McLean, C and Bye, N and Beart, PM and Devenish, RJ and Crack, PJ, Evidence for the recruitment of autophagic vesicles in human brain after stroke, Neurochemistry international, 96 pp. 62-68. ISSN 0197-0186 (2016) [Refereed Article]


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Copyright Statement

Copyright 2016 Elsevier Ltd.

DOI: doi:10.1016/j.neuint.2016.02.016

Abstract

Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.

Item Details

Item Type:Refereed Article
Keywords:stroke; autophagy
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Bye, N (Dr Nicole Bye)
ID Code:120858
Year Published:2016
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2017-08-31
Last Modified:2017-09-07
Downloads:5 View Download Statistics

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