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Evidence for the recruitment of autophagic vesicles in human brain after stroke
Citation
Frugier, T and Taylor, JM and McLean, C and Bye, N and Beart, PM and Devenish, RJ and Crack, PJ, Evidence for the recruitment of autophagic vesicles in human brain after stroke, Neurochemistry international, 96 pp. 62-68. ISSN 0197-0186 (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 Elsevier Ltd.
DOI: doi:10.1016/j.neuint.2016.02.016
Abstract
Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | stroke; autophagy |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Bye, N (Dr Nicole Bye) |
| ID Code: | 120858 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 4 |
| Deposited By: | Pharmacy |
| Deposited On: | 2017-08-31 |
| Last Modified: | 2017-11-09 |
| Downloads: | 20 View Download Statistics |
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