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Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas
journal contribution
posted on 2023-05-19, 10:50 authored by Hsu, SS, Chen, CH, Guei-Sheung LiuGuei-Sheung Liu, Tai, MH, Wang, JS, Wu, JC, Kung, ML, Chan, EC, Liu, LFHepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis are yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients, with prevalence of nuclear HDGF predicting short survival of patients with GBM after surgery. To delineate the mitogenic role of HDGF in gliomagenesis, an adenoviral-expressed HDGF small interfering RNA (Ad-HDGF siRNA) was used to knock down expression of nuclear HDGF. After knocking down nuclear HDGF expression in human GBM cells, cell growth and cell invasion and induction on apoptosis by caspase-3 activation were significantly inhibited. We conclude that HDGF is a mitogenic growth factor in glioma progression and can be a useful prognostic marker for GBM and therapeutic target for clinical management of glioma in the future.
History
Publication title
Journal of Neuro-OncologyVolume
107Pagination
101-109ISSN
0167-594XDepartment/School
Menzies Institute for Medical ResearchPublisher
Kluwer Academic PublPlace of publication
Van Godewijckstraat 30, Dordrecht, Netherlands, 3311 GzRights statement
?Copyright Springer Science+Business Media, LLC. 2011Repository Status
- Restricted