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Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas

Citation

Hsu, SS and Chen, CH and Liu, GS and Tai, MH and Wang, JS and Wu, JC and Kung, ML and Chan, EC and Liu, LF, Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas, Journal of Neuro-Oncology, 107, (1) pp. 101-109. ISSN 0167-594X (2012) [Refereed Article]

Copyright Statement

Copyright Springer Science+Business Media, LLC. 2011

DOI: doi:10.1007/s11060-011-0733-z

Abstract

Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis are yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients, with prevalence of nuclear HDGF predicting short survival of patients with GBM after surgery. To delineate the mitogenic role of HDGF in gliomagenesis, an adenoviral-expressed HDGF small interfering RNA (Ad-HDGF siRNA) was used to knock down expression of nuclear HDGF. After knocking down nuclear HDGF expression in human GBM cells, cell growth and cell invasion and induction on apoptosis by caspase-3 activation were significantly inhibited. We conclude that HDGF is a mitogenic growth factor in glioma progression and can be a useful prognostic marker for GBM and therapeutic target for clinical management of glioma in the future.

Item Details

Item Type:Refereed Article
Keywords:HDGF, Glioma, Tumorigenesis, Prognostic factor, Adenovirus-mediated siRNA gene delivery
Research Division:Technology
Research Group:Medical Biotechnology
Research Field:Gene and Molecular Therapy
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Inherited Diseases (incl. Gene Therapy)
Author:Liu, GS (Dr Guei-Sheung Liu)
ID Code:120841
Year Published:2012
Web of Science® Times Cited:19
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-31
Last Modified:2017-11-03
Downloads:0

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