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Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas

journal contribution
posted on 2023-05-19, 10:50 authored by Hsu, SS, Chen, CH, Guei-Sheung LiuGuei-Sheung Liu, Tai, MH, Wang, JS, Wu, JC, Kung, ML, Chan, EC, Liu, LF
Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis are yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients, with prevalence of nuclear HDGF predicting short survival of patients with GBM after surgery. To delineate the mitogenic role of HDGF in gliomagenesis, an adenoviral-expressed HDGF small interfering RNA (Ad-HDGF siRNA) was used to knock down expression of nuclear HDGF. After knocking down nuclear HDGF expression in human GBM cells, cell growth and cell invasion and induction on apoptosis by caspase-3 activation were significantly inhibited. We conclude that HDGF is a mitogenic growth factor in glioma progression and can be a useful prognostic marker for GBM and therapeutic target for clinical management of glioma in the future.

History

Publication title

Journal of Neuro-Oncology

Volume

107

Pagination

101-109

ISSN

0167-594X

Department/School

Menzies Institute for Medical Research

Publisher

Kluwer Academic Publ

Place of publication

Van Godewijckstraat 30, Dordrecht, Netherlands, 3311 Gz

Rights statement

?Copyright Springer Science+Business Media, LLC. 2011

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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