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Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy

Citation

Neuhaus, AA and Sutherland, B and Buchan, AM, Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy, Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchak and JH Zhang (ed), Switzerland, pp. 537-556. ISBN 978-3-319-45345-3 (2017) [Research Book Chapter]

Copyright Statement

Copyright 2017 Springer International Publishing Switzerland

DOI: doi:10.1007/978-3-319-45345-3_22

Abstract

Ischaemic stroke is a major global cause of disability and death, yet the therapeutic options currently available for stroke are very limited. The only effective acute treatments of ischemic stroke revolve around restoring patency to the occluded artery through degradation (intravenous thrombolysis) or mechanical removal of the clot [Int J Stroke 10:11681178, 2015; Brain 136:35283553, 2013]. However, there is an increasing body of evidence to suggest that even following recanalization of the large vessel, the post-ischemic microvasculature remains dysfunctional and does not necessarily allow effective reperfusion. Contributors to this phenomenon include astrocyte swelling and compression of microvessels, obstruction of flow due to inflammatory changes, leukocyte adhesion and thrombosis, and the constriction of capillaries by pericytes dying in rigor [Shock 8:95101, 1997; J Cereb Blood Flow 36:451455, 2016]. This chapter will provide an overview of microvascular function in health, describe the pathological changes that occur following ischemia and reperfusion, and explore the role of the microvasculature, with a focus on pericytes as a potential therapeutic target in ischemic stroke.

Item Details

Item Type:Research Book Chapter
Keywords:Pericyte, blood flow, stroke, brain
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Sutherland, B (Dr Brad Sutherland)
ID Code:120823
Year Published:2017
Deposited By:Medicine (Discipline)
Deposited On:2017-08-30
Last Modified:2018-01-18
Downloads:0

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