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Influence of liquid and vapourized solvents on explosibility of pharmaceutical excipient dusts


Hossain, MN and Amyotte, P and Abuswer, M and Dastidar, A and Khan, FI and Eckhoff, R and Chunmiao, Y, Influence of liquid and vapourized solvents on explosibility of pharmaceutical excipient dusts, Process Safety Progress, 33, (4) pp. 374-379. ISSN 1066-8527 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American Institute of Chemical Engineers

DOI: doi:10.1002/prs.11673


Hybrid mixtures of a combustible dust and flammable gas are found in many industrial processes. Such fuel systems are often encountered in the pharmaceutical industry when excipient (nonpharmaceutically active ingredient) powders undergo transfer in either a dry or solvent prewetted state into an environment possibly containing a flammable gas. The research described in this article simulated the conditions of the above scenarios with microcrystalline cellulose and lactose as excipients, and methanol, ethanol, and isopropanol as solvents. Standardized dust explosibility test equipment (Siwek 20-L explosion chamber, MIKE 3 apparatus, and BAM oven) and ASTM test protocols were used to determine the following explosibility parameters: maximum explosion pressure (Pmax), volume-normalized maximum rate of pressure rise (KSt), minimum explosible concentration (MEC), minimum ignition energy (MIE), and minimum ignition temperature (MIT). The experimental results demonstrate the significant enhancements in explosion likelihood and explosion severity brought about by solvent admixture in either mode. The extent of solvent influence was found to be specific to the given excipient and method of solvent addition. Solvent burning velocity considerations help to account for some of the experimental observations but for others, a more rigorous evaluation of solvent and excipient physical property data is needed.

Item Details

Item Type:Refereed Article
Keywords:dust explosion, hybrid mixture, prewetting, solvent admixture, dust, equipment testing, explosions, firedamp, ignition, mixtures, solvents, dust explosion, hybrid mixtures, maximum explosion pressure, maximum rate of pressure rise, pre-wetting
Research Division:Engineering
Research Group:Engineering practice and education
Research Field:Risk engineering
Objective Division:Manufacturing
Objective Group:Human pharmaceutical products
Objective Field:Human pharmaceutical products not elsewhere classified
UTAS Author:Khan, FI (Professor Faisal Khan)
ID Code:120746
Year Published:2014
Web of Science® Times Cited:7
Deposited By:NC Maritime Engineering and Hydrodynamics
Deposited On:2017-08-30
Last Modified:2017-11-06

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