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Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD)

Citation

Sohal, SS, Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD), Respiratory Investigation, 55, (2) pp. 104-113. ISSN 2212-5345 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 Crown Copyright

DOI: doi:10.1016/j.resinv.2016.11.006

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is mainly caused by smoking and presents with shortness of breath that is progressive and irreversible. It is a worldwide health problem and the fourth most common cause of chronic disability and mortality (even in developed countries). It is a complex disease involving both the airway and lung parenchyma. Small-airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small-airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (EMT-type-3), EMT may well also be linked to the development of airway epithelial cancer, which is closely associated with COPD and predominantly observed in large airways. Vascular remodeling has also been widely reported in smokers and patients with COPD but the mechanisms behind it are poorly understood. It is quite possible that the process of endothelial to mesenchymal transition (EndMT) is also active in COPD lungs, in addition to EMT. Understanding these pathological mechanisms will greatly enhance our knowledge of the immunopathology of smoking-related lung disease. Only by understanding these processes can new therapies be developed.

Item Details

Item Type:Refereed Article
Keywords:COPD, ICS, inflammation, lung cancer, EMT, EndMT, fibrosis
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:120625
Year Published:2017
Web of Science® Times Cited:7
Deposited By:Health Sciences
Deposited On:2017-08-29
Last Modified:2018-09-13
Downloads:0

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