Liu, RS and Mensah, FK and Carlin, J and Edwards, B and Ranganathan, S and Cheung, M and Dwyer, T and Saffery, R and Magnussen, CG and Juonala, M and Wake, M and Burgner, DP, on behalf of the Child Health CheckPoint Investigator Group, Socioeconomic position is associated with carotid intima-media thickness in mid-childhood: the longitudinal study of Australian children, Journal of the American Heart Association, 6, (8) Article e005925. ISSN 2047-9980 (2017) [Refereed Article]
Copyright 2017 The Authors. Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) https://creativecommons.org/licenses/by-nc/3.0/
Methods and Results: Data were obtained from 1477 families participating in the Child Health CheckPoint study, nested within the Longitudinal Study of Australian Children. Disadvantaged family and neighborhood SEP was cross-sectionally associated with thicker maximum carotid IMT in separate univariable linear regression models. Associations with family SEP were not attenuated in multivariable analyses, and associations with neighborhood SEP were attenuated only in models adjusted for family SEP. The difference in maximum carotid IMT between the highest and lowest family SEP quartile measured at ages 10 to 11 years was 10.7 μm (95% CI, 3.4-18.0; P=0.004), adjusted for age, sex, pubertal status, passive smoking exposure, body mass index, blood pressure, and arterial lumen diameter. In longitudinal analyses, family SEP measured as early as age 2 to 3 years was associated with maximum carotid IMT at ages 11 to 12 years (difference between highest and lowest quartile: 8.5 μm; 95% CI, 1.3-15.8; P = 0.02). No associations were observed between SEP and mean carotid IMT.
Conclusions: We report a robust association between lower SEP in early childhood and carotid IMT in mid-childhood. Further investigation of mechanisms may inform pediatric cardiovascular risk assessment and prevention strategies.
|Item Type:||Refereed Article|
|Keywords:||atherosclerosis, CheckPoint, prevention, socioeconomic position, subclinical atherosclerosis risk factor|
|Research Division:||Health Sciences|
|Research Field:||Epidemiology not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Magnussen, CG (Associate Professor Costan Magnussen)|
|Web of Science® Times Cited:||9|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||80 View Download Statistics|
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