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Epithelial-mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease
journal contribution
posted on 2023-05-19, 10:31 authored by Jolly, MK, Ward, C, Mathew Eapen, Stephen MyersStephen Myers, Hallgren, O, Levine, H, Sukhwinder SohalSukhwinder SohalEpithelial-mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease.
History
Publication title
Developmental DynamicsVolume
247Pagination
346-358ISSN
1058-8388Department/School
School of Health SciencesPublisher
Wiley-LissPlace of publication
United StatesRights statement
Copyright 2017 Wiley Periodicals, Inc.Repository Status
- Restricted