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Epithelial-mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease

journal contribution
posted on 2023-05-19, 10:31 authored by Jolly, MK, Ward, C, Mathew Eapen, Stephen MyersStephen Myers, Hallgren, O, Levine, H, Sukhwinder SohalSukhwinder Sohal
Epithelial-mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease.

History

Publication title

Developmental Dynamics

Volume

247

Pagination

346-358

ISSN

1058-8388

Department/School

School of Health Sciences

Publisher

Wiley-Liss

Place of publication

United States

Rights statement

Copyright 2017 Wiley Periodicals, Inc.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified