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Epithelial–Mesenchymal Transition, a Spectrum of States: Role in Lung Development, Homeostasis, and Disease

Citation

Jolly, MK and Ward, C and Eapen, MS and Myers, S and Hallgren, O and Levine, H and Sohal, SS, Epithelial-Mesenchymal Transition, a Spectrum of States: Role in Lung Development, Homeostasis, and Disease, Developmental dynamics ISSN 1058-8388 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Wiley Periodicals, Inc.

DOI: doi:10.1002/dvdy.24541

Abstract

Epithelial-mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease.

Item Details

Item Type:Refereed Article
Keywords:COPD, IPF, ICS, inflammation, lung cancer, EMT
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Eapen, MS (Mr Mathew Eapen)
Author:Myers, S (Dr Stephen Myers)
Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:120615
Year Published:2017
Deposited By:Health Sciences
Deposited On:2017-08-29
Last Modified:2017-11-13
Downloads:0

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