Fed-batch fermentation process is an effective method for production. Due to the various feeding streams and operational conditions in different fed-batches, usually it is difficult to formulate a kinetics-based ordinary differential equations model for industrial fed-batch fermentation process. On the other hand, there are plenty of historical data collected during the fermentation process. In this paper, we firstly applied the graphical modeling method to model the fed-batch fermentation process. In this proposed method, the missing data within records are imputed, and then, the correlations between variables are determined by the low order conditional independence method, after that, the parameters of these related variables are learned by the multivariate auto regressive method. The calculation of L-lysine fed-batch fermentation process demonstrates the effectiveness of the proposed approximate model method.

Item Type:	Refereed Conference Paper
Keywords:	dynamic Bayesian network, Gaussian approximate, missing data imputation, process modelling, fed-batch fermentation
Research Division:	Technology
Research Group:	Industrial Biotechnology
Research Field:	Fermentation
Objective Division:	Expanding Knowledge
Objective Group:	Expanding Knowledge
Objective Field:	Expanding Knowledge in Engineering
Author:	Khan, FI (Professor Faisal Khan)
ID Code:	120533
Year Published:	2015
Deposited By:	NC Maritime Engineering and Hydrodynamics
Deposited On:	2017-08-28
Last Modified:	2017-10-17
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