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Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

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Lophatananon, A and Stewart-Brown, S and Kote-Jarai, Z and Olama, AAA and Garcia, SB and Neal, DE and Hamdy, FC and Donovan, JL and Giles, GG and Fitzgerald, LM and Southey, MC and Pharoah, P and Pashayan, N and Gronberg, H and Wiklund, F and Aly, M and Stanford, JL and Brenner, H and Dieffenbach, AK and Arndt, V and Park, JY and Lin, HY and Sellers, T and Slavov, C and Kaneva, R and Mitev, V and Batra, J and Spurdle, A and Clements, JA and Easton, D and Eeles, RA and Muir, K, APCB BioResource, The PRACTICAL consortium, Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium, British Journal of Cancer, 117, (5) pp. 734-743. ISSN 0007-0920 (2017) [Refereed Article]


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Copyright The Author(s). Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1038/bjc.2017.231

Abstract

Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.

Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.

Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.

Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

Item Details

Item Type:Refereed Article
Keywords:height, SNPs, gene and environment interaction, prostate cancer
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:120477
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-25
Last Modified:2017-09-21
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