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Interplay of the quality of ciprofloxacin and antibiotic resistance in developing countries


Sharma, D and Patel, RP and Zaidi, STR and Sarker, MMR and Lean, QY and Ming, LC, Interplay of the quality of ciprofloxacin and antibiotic resistance in developing countries, Frontiers in Pharmacology, 8 Article 546. ISSN 1663-9812 (2017) [Refereed Article]


Copyright Statement

Copyright 2017 The Author(s) Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fphar.2017.00546


Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, the availability and use of substandard and spurious quality of oral ciprofloxacin formulations in the developing countries has been thought to have contributed toward increased risk of treatment failure and bacterial resistance. Therefore, quality control and bioequivalence studies of the commercially available oral ciprofloxacin formulations should be monitored. Appropriate actions should be taken against offending manufacturers in order to prevent the sale of substandard and spurious quality of ciprofloxacin formulations.

Item Details

Item Type:Refereed Article
Keywords:antimicrobials, antibiotic resistance, ciprofloxacin, quality assurance, substandard drug, spurious drug, pharmacovigilence and drug monitoring, drug regulatory system, fluoroquinolones
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharma, D (Mrs Deepali Sharma)
UTAS Author:Patel, RP (Dr Rahul Patel)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Ming, LC (Dr Long Ming)
ID Code:120462
Year Published:2017
Web of Science® Times Cited:41
Deposited By:Pharmacy
Deposited On:2017-08-25
Last Modified:2018-12-13
Downloads:156 View Download Statistics

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