Boyd, A and Stoodley, P and Richards, D and Hui, R and Harnett, P and Vo, K and Marwick, T and Thomas, L, Anthracyclines induce early changes in left ventricular systolic and diastolic function: A single centre study, PLoS ONE, 12, (4) Article e0175544. ISSN 1932-6203 (2017) [Refereed Article]
Copyright 2017 Boyd et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Methods and Results: 140 patients were assessed by detailed echocardiography before and within seven days post treatment. LV ejection fraction (LVEF), global longitudinal strain (GLS), strain rate and radial and circumferential strain were assessed. Additionally, left atrial volumes and LV diastolic parameters were evaluated. LVEF although reduced after treatment, remained within the normal range (60 ± 3% vs. 59 ± 3%, p = 0.04). Triplane GLS was significantly reduced after treatment (-20.0 ± 1.6% vs. -19.1 ± 1.8%, p < 0.001). Subclinical LV dysfunction (> 11% reduction in GLS compared to before therapy) occurred in 22% (29/135). Impaired diastolic function grade significantly increased from 46% to 57% (p < 0.001) after treatment. Furthermore, diastolic dysfunction was more common in the subgroup group with reduced systolic GLS compared to those without changes in GLS (30% vs. 11%; p = 0.04). No risk factors or clinical parameters were associated with the development of subclinical LV dysfunction; however the percentage change in early diastolic strain rate and the E velocity were independent predictors of > 11% reduction in GLS.
Conclusion: Twenty two percent of patients had subclinical LV dysfunction by GLS, whilst none had cardiotoxicity defined by LVEF, demonstrating that GLS is more sensitive for detection of subclinical LV systolic dysfunction immediately after anthracycline therapy. Diastolic dysfunction increased, particularly in the group with reduced GLS, demonstrating the close pathophysiological relationship between systolic and diastolic function.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Marwick, T (Professor Tom Marwick)|
|Web of Science® Times Cited:||9|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||30 View Download Statistics|
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