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Expression of CCR6 on B cells in systemic lupus erythematosus patients

Citation

Lee, AYS and Bannan, JL and Adams, MJ and Korner, H, Expression of CCR6 on B cells in systemic lupus erythematosus patients, Clinical Rheumatology, 36, (6) pp. 1453-1456. ISSN 0770-3198 (2017) [Refereed Article]

Copyright Statement

International League of Associations for Rheumatology (ILAR) 2017

DOI: doi:10.1007/s10067-017-3652-3

Abstract

B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.

Item Details

Item Type:Refereed Article
Keywords:B cells, CCR6, Chemokines, SLE
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Lee, AYS (Dr Adrian Lee)
Author:Bannan, JL (Ms Jennifer Bannan)
Author:Adams, MJ (Dr Murray Adams)
Author:Korner, H (Professor Heinrich Korner)
ID Code:120437
Year Published:2017
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-24
Last Modified:2018-06-21
Downloads:0

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