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Roles of SAMHD1 in antiviral defense, autoimmunity and cancer

Citation

Li, M and Zhang, D and Zhu, M and Shen, Y and Wei, W and Ying, S and Korner, H and Li, J, Roles of SAMHD1 in antiviral defense, autoimmunity and cancer, Reviews in Medical Virology, 27, (4) Article e1931. ISSN 1052-9276 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 John Wiley & Sons, Ltd.

DOI: doi:10.1002/rmv.1931

Abstract

The enzyme, sterile α motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV-1) by hydrolyzing intracellular deoxynucleotide triphosphates (dNTPs) in myeloid cells and resting CD4+ T cells. This dNTP degradation reduces the dNTP concentration to a level insufficient for viral cDNA synthesis, thereby inhibiting retroviral replication. This antiviral enzymatic activity can be inhibited by viral protein X (Vpx). The HIV-2/SIV Vpx causes degradation of SAMHD1, thus interfering with the SAMHD1-mediated restriction of retroviral replication. Recently, SAMHD1 has been suggested to restrict HIV-1 infection by directly digesting genomic HIV-1 RNA through a still controversial RNase activity. Here, we summarize the current knowledge about structure, antiviral mechanisms, intracellular localization, interferon-regulated expression of SAMHD1. We also describe SAMHD1-deficient animal models and an antiviral drug on the basis of disrupting proteasomal degradation of SAMHD1. In addition, the possible roles of SAMHD1 in regulating innate immune sensing, Aicardi-Goutières syndrome and cancer are discussed in this review.

Item Details

Item Type:Refereed Article
Keywords:Aicardi-Goutieres syndrome, SAMHD1, antiviral mechanism, cancer
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Korner, H (Professor Heinrich Korner)
ID Code:120405
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-23
Last Modified:2018-12-13
Downloads:0

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